I will use time on the dyno to give examples. It's easier on dyno than it is in the car. You are not fixated on little things - like guardrails or competitors, or traffic, or your girlfriend, etc.
You can hear it - the engines sound will get "raspy" or coarse right at the upper RPM ranges. If you pull the rocker arms you will see a "butterfly", "bow tie", or "criss-cross" wear pattern on the valve tips. The dyno sheet will show a sharp edged and significant drop in power/torque at high RPM instead of a smooth roll over. If you have clear evidence you will sometimes see a corresponding +/-5psi drop in oil pressure as the parts separate.
In the car - if you are going to 6500 RPM with normal non-trick hydraulic roller parts you are floating the valves. Pretty much guaranteed.