Is it an oversize radiator, or stock size? Crossflow or downflow? What size are the tubes in the radiator? Also, are you using electric fans, and if so, what kind?
On my higher horsepower cars I've always ended up notching the frame rails to fit a 31" wide crossflow aluminum radiator with 2 rows of tubes, either 1" or 1.25". Usually a Griffin or a C&R. Also, the only electric fans that really work are Spal; if you've got a DeRaille or Flex-a-lite electric fan they are pretty much no good for a higher HP application, especially in a tight engine compartment like a Mustang.
Not that the pulleys won't help, but if you try those and still have issues, I'd be looking at the radiator and fans.