I have built and dyno'd TW engines ranging from 517 HP (mild 452 w/ Ford TW) to 633 HP with a Dove headed 496 and a Ford TW, in between 550 HP 457s and 630-ish 485s. Ironically, the 633 HP 496 made about the same with a pair of Edelbrock 600s as it did with the 600 Holleys as we troubleshooted what turned out to be ignition.
On the 457, we saw no change in peak HP from 465 vac secs, to 600s to 750 annular. However, on the recent 452 we saw almost 15 HP from using a pair of Super Suckers and no other changes. So I think that 550 HP 457 had more in it with the 750s if we controlled flow a little better. Incidentally, although all the carbs made around 550 HP on that 457, Drews 750s made 30 ft lbs more torque, nothing to sneeze at.
I love the TW manifolds, and I like a progressive linkage vac sec on them. I think it's hard to beat a tuned pair of 750s on all but the smallest engines, but I don't see any benefit of turning them sideways for more carb, except in very specific peak power needs, like a pure drag car, and even then, it'd have to be a real big boy to need more.