I have a close combination in my 68 Mustang daily driver, 30 over 428CJ, stock cast iron CJ heads, 10.5:1 compression ratio, a Comp 294S solid cam, FPA headers, and one of my intake adapters with an Edelbrock Torker intake and a Holley double pumper carb. I run 12 degrees initial timing and 36 total, all in by 3000 RPM. 4.11 gears and a T-56 Magnum transmission. Coolant temperature always stays in the 170-180 degree range, and no fresh air induction, so it does get pretty hot under the hood. I do have an electric fuel pump with a return style fuel system, which solves a lot of the hot weather problems.
I only get 91 octane here, 10% ethanol, and the car runs fine on that fuel with no octane boosters, in weather up to 90 degrees (which is about as hot as it gets here). No pinging or any other fuel related problems. I don't know your cam specs, but as long as its not a super mild cam, and you have a good solution for fuel delivery that will keep the fuel cool, I think you should be fine on 93 octane.