I used to use Rev-X a lot. But it's just a friction modifier mostly according to the lab tests I've done on a new un-opened bottle. I only use it when customers specifically want it these days. It won't hurt anything using it, but with a HEUI fuel system your best bet is a quality oil changed at reasonable intervals. The biggest issue with the second gen HEUI injectors is that they spool valves can be bent if you over-pressure them with cold oil. I always change the cold oil temp tables for ICP so it's easier on them, but then you need to let the truck run for a bit and warm up or it is pretty lazy with the low ICP pressure.
A good 15w40 (I prefer Delo because it's got some of the best anti-foam additives and is pretty shear stable, both important in HEUI fuel systems) and block heater or a 5w40 and run it for the next 500k miles.
Would highly recommend full EGR delete, a good custom tune, new OEM oil cooler and coolant filter for reliability.