Some years ago---actually quite a few, now that I think about it---I put a 460 CID Super Cobra Jet engine I'd built up, with the very first set of heads released by Trick Flow, into the '72 Pinto I was doing up as a project car for Super Ford Magazine. It was designed primarily for the street.
Dave Lyall was working from Carl Holbrook's shop at the time and he did the basic chassis modifications. We put in 2" X 3" frame rails, let into the floorpan, from in front of the radiator to the back bumper, with all necessary crossmembers to fit. The engine set mostly back of the original firewall line and the car only held two people.
The front suspension was entirely fabricated, and made use of Koni double adjustable shocks, but instead of coil-over springs, I used a transverse fibreglas single leaf set-up that was available at the time for circle track racing. (The design was soon after outlawed as giving too much advantage.) If I were to do it now, I'd just use coil-overs.
You must beef-up the chassis to make it possible to use the power you'll have available. Using a MII front suspension will complicate your front lay-out since it relies on the crossmember at that location and that'll complicate engine placement. I had enough engine setback that the damper was behind the spindle centerline But I had a crossmember there to help control the torque that'd otherwise soon bend the frame out of shape. The engine was mounted with motor-plates fore-'n'-aft.
If you're aware of all such things, you'll be able, together with your fabricator, to come up with a solution that'll fit your particular set of circumstances.
KS
