At that level of a build, in that vehicle, I don't think your mileage should suffer at all. I get 12 and 6-8, towing a 9500# trailer with a '70 F350 dumptruck with 4:11 gears and 28" tires. That's with an all iron 390 in a much heavier truck. I used to get 14-16 in my '68 F250 Highboy. Both were/are non-strokers with simple and mild, but solid builds. From what it sounds like on your build, your driving style will be a big factor in what your final mileage will be, but with modern cams and a good tune, it's common to pick up a big chunk of power and still retain the same mileage over stock, if not even improve on it.