I did that exact build with Blair Patrick. F250 T19 manual trans, 3.54 gears, 265/75R16 tires.
We built a 445 engine, ported D2TE heads with CJ valves, iron CJ intake, hydraulic roller cam/valvetrain, Holley Sniper EFI. Cam is a custom spec, 0.520 lift I/E, 212/218 duration at fifty. Blair can give you more of the details I'm sure.
Engine idles fairly smooth at 750rpm, but pulls like a beast up to 4500.