Well, here's how I'm looking at it:
A 482 with good heads will make at least 550 hp. Even if you stayed with a 4.250" stroke, made 550 hp, and then sprayed 150 on top of it, I wouldn't feel comfortable with a cast crank in that situation, so you're looking at a steel crank. If you're gonna pay for a steel crank, you're looking at saving at least a couple hundred bucks by going with an RPM 4.375" crank, even if you have to touch grind the mains/rods. You're also adding cubic inches, especially if you go past the standard 4.250" bore size.
The only con is that you have to pay a little extra attention to the rod/cam clearance, depending on the connecting rods that you choose. Some get close, some don't.
If you go with a 4.375" stroke, you will need a 6.700" rod and the piston will come out to be ~1.265" with a 10.150" deck height. You will need to cut the decks on your BBM block. They come in at around 10.160", but there's enough variance that they need to be trued up. I usually aim for 10.150". For 700-750 hp, I'd bypass a Scat rod and use something like a Crower, Callies, Oliver, etc.
There's nothing wrong with the 4.250" stroke, but if you're aiming for big horsepower with the spray, I see it as an opportunity to save some money and add some displacement with the RPM. Just my thinking.