I'm a big fan of a properly designed PCV, and other means of creating negative pressure in the crankcase. As Barry said, vacuum pumps always boost power through better ring seal......always. On race cars where vac pumps are not permitted, the pan evacuation hoses to the headers are definitely worth something. It is very important to monitor the check valves to make sure they are checking properly. They will blow out periodically, and can pressurize the crankcase if the valves blow out.
In some cases, like Stock Eliminator drag engines, neither vac pumps nor pan evacs are legal. Sealed PCV systems absolutely DO help Stockers. We adjust the spring tension in the inline check valves, and plug directly into the manifold, with no other venting. Anytime there is vacuum, and with special check valves in play, it makes negative pressure. The vacuum will last usually through the middle of second gear if you have good ring seal......it then eventually goes to zero, but then in high gear, when rules limit carb size, the vacuum returns. I wouldn't run a Stocker without PCV.
On street pcv systems, I think they are very beneficial. Most people get it half-right, and then it does nothing. The PCV valve should connect to manifold vacuum. The other "breather" should have a much lighter inline check valve(lighter than the pcv), turned the opposite direction in terms of flow, and connected to the AIR CLEANER. Doing this will check it off and the pcv valve will evacuate at idle and part-throttle, without just pulling air and "leaking" from an open breather on the other side. At wide open throttle, the pcv valve will close, but the negative pressure inside the air breather above the carb or throttle body will pull on the lighter check valve in the other valve cover and insure no positive pressure at WOT. Back off the throttle, and the breather will check off and your pcv will open.....back to vacuum again. If the system is not SEALED and properly "checked" on both sides, the pcv valve really won't do much in terms of benefits to engine performance. A pcv valve and an opposite open breather will reduce the stink as was mentioned above, but will not create negative crankcase pressure. The '70s Ford pcv was a wonderful setup. The filter in the air cleaner had enough resistance to allow the pcv to work, and vented enough at WOT, which was sporadic, to prevent crankcase pressure during those events.