I agree with Tommy, I like the sequential stuff and wouldn't do my Mustang different. However I have done a few of the TBs so far on other poeple's cars, and they do work great on the street. I did a Powerjection and it took a 355 Chebby Q-jet and made it feel like it added 50 ft lbs, while adding smart fast idle, compensation for A/C, demands from the etc. The Holley I did was older, but even then it felt like it gained torque.
I am on the fence for my F100, Jay's write up showed a cost effective way (after the 700 dollar intake is bought) but to be honest, a bolt on TB gets me 90% of the way there if it's decent quality
FYI - the Powerjection was fully programmable, logged for you, and IMHO ahead of it's time, but the parts that came with it were so cheap and the program to set it up was so poor that I am turned off.