On any of the FE blocks that started as 4.050" bores, it is always advisable to sonic test the cylinder walls for thickness if you are thinking of boring them over .040 or .050 or more. At 4.125" bore, a block is extremely thin in most instances, and to put a longer stroke in that block would put excessive side loading on the cylinders, and promote splitting them. A 4.250" stroke is the same cost in most examples as the 4.125" stroke, so pick whatever size you want, but remember the cylinder walls will be the weak point in the build. Joe-JDC