Speaking VERY generally, a 2X4 FE will make more steam and go faster than a single carb. It has a huge amount to do with how much a particular engine demands. The bigger the mill underneath, the more a 2X4 will help, as long as it is a good enough manifold. A tunnel wedge is borderline on being too big for a 427, and it is too big for anything smaller. I have a customer with a 511 cube roller cam FE. We did the engine with a Victor that I modified extensively, and a 4150 that most would call a "950". It made 820 hp and a little over 700 ft-lbs torque. When we freshened the engine, I did a tunnel wedge in similar fashion, and two 850's. On the same dyno, same cam, same everything, it then made 880 hp and 770 ft-lbs torque. A huge difference. By contrast, I did a 445 for a nice man with a LR 2X4 and two 600's that made 580 power and just under 600 torque. The very same combo with a RPM manifold and a 750 DP made 560 power and a tad MORE torque than the 2X4. If we go smaller and less, the difference will be smaller and less, until we finally get to the point where the single four suits the demands the best, and then the single will win.
On heads that are too big for an engine, a smaller (single four) manifold will crutch the issue often times. My opinion is that on the combo Brent described, he has a "mid-size" FE by today's standards, with a "too big" port, so the single four with less volume helps the "big head" problem and the single four shines.
A dual plane HR manifold with two 715's is 40 hp and no torque, better than the same engine with a dual plane and a single 780. I did that back to back once on a 427 cube flat tappet. The curves are different, and the single carb has better torque way down low, and falls off sooner with a different bell shape of the power curve.
It is hard to make a blanket statement about one versus two without looking at the other factors. I did not mention T-rams for either one, but in that world, the dual carbs are absolutely better, as others have mentioned.
That should be a nice street driver at 10.25 C/R, and with that 106 cam it'll sound like John Force's funny car.