In some cases with EFI it's best to notch, as you should have the idle air control able to affect both sides.
With a carb, when Edelbrock first started notching the BBC and other manifolds I called and asked a guy I knew in their dyno shop (not even sure if the shop exists anymore) , and they said they saw no reason not to and most of the new releases would be notchied. However, they told me leaving the ends as a flow director worked pretty well and of course, ensure a blunt edge.
I never did a back to back test, and as others said, other factors in play, but I continue to do it, along with a little rubbing on the plenum roof turn.
I attached a pic of a BT and an Edelbrock RPM for fun
The BT was for EFI, the RPM was on my Mustang and really did well on a 489 inch FE with a 1000 cfm carb, went on to sell the combo to a forum member and had great street feedback as well.
As far as spacers, same as others, some you expect will do great things, some you expect will do nothing, and in the end, the engine decides
