I ran bottle and bottles through my F100 in the late 80s, early 90s, and we also ran a CJ5 mud bogger with a 351W with N2O. That was a wild little machine, 38 inch mudders, 351W on juice, Toploader and 4.11s, no roof and a roll cage. Felt much faster than it probably was
We didn't change the carb settings much, most plate systems are pretty rich on the fuel side, the key was to make sure the fuel supply to the nitrous system was up to snuff so it didn't go lean.
Timing was important, as well as a little cooler plug. The Jeep was locked out, so we just cranked it back, but truck was a street/work truck, and I was young and dumb, so I used to just set timing at stock specs and disconnect the vac advance. It did fine, but it was more for horsing around than real performance.
We never broke anything on the Jeep, and the truck was in so many configurations when I was young, I didn't either, but probably would have if I wasn't always taking it apart and trying something new LOL