If you are building an engine to specifications based on use, no engine is different. It's just different data to get you there.
However, if you are talking quirks, every engine has them. V-6 GM and V-8 Mopars have external oil pumps, Chevy small blocks require main cap replacement for big power, Chevys have odd nylon oil pump drive collars, FEs have intakes and rockers that have to be assembled in a different way, they are all quirky. Small blocks, low HP especially, of all types, seem to have a little less weirdness, but in the end, nothing fancy, physics is physics and machined parts are machined parts
The heads are a little less "good" than 460 and Rat motors, and a little less supported by aftermarket than SBF and SBC, but that is just supply and demand.
As far as big compression and cam, again, depends on use, not the FE specific, the dyno run I just did was 10.4 and 237 @ .050 114 LSA. That's a truck cam in my world LOL but made over 500 hp and matched the use of the car.