OK, lots of assumptions here, but if you can keep open up the valve bowl and still keep a consistent taper from intake surface to valve seat, I'd go 2.19
Not that it's a huge amount, but assuming a valve size of 2.19 vs 2.09 and a lift of .530, you are going to get about 5% more curtain area at any given lift.
Seeing you have a big bore, and assuming you port the bowls, I'd go big, it sure wont hurt anything and you have a LONG way to go on a 427 bore before there are any intake issues..