"Makes me curious if there is a significant variation of hardness in FE castings or if there are any patterns that develop year to rear, plant to plant, by engine size, etc."
I would be very surprised to see any large variation even across various foundries and time (FE's years of production). Having some knowledge of GM's old Central Foundry Division's operations (sorry, no FoMoCo background) they did carefully choose their iron used to be melted and poured. Even with some variations in the mix of metals used, I'm not sure that hardness varied much of at all.
I do know that casting irregularities were a major issue (short shots, shifted molds, damaged core boxes, unexpected pinholes and a raft of other issue) for all the plants. Oddly, I was told that bad runs were simply crushed and thrown back into the pile for re-melting. Q.C. back then was badly missing and all the casting operations were terrible places to work in, hence poor operations lead to lots of rejects.