Hoo boy! Calculating actual loads in a multi-cylinder engine block is a major job. It's a three-dimensional problem since loads / vibrational energy are traveling along the crank. Throw in some external balance, like on a 428, and it gets crazy.
My resource on this matter, "The Internal-Combustion Engine in Theory and Practice", by Charles Fayette Taylor, devotes about forty pages of scary- looking equations to this subject.
Yeah I was a Ford Engine Engineer, and I have designed engine blocks, but today I wouldn't even attempt such a calculation. This is why God invented finite element analysis

Yes it is a big FEA model you would have to build for an FE, but at least it would give you excellent data that points out where the weak areas are for your given load case.
FEA is how the big boys do it now. It's relatively routine for them, and possible (but very difficult) for someone like me with a reasonably normal computer and software. I would rather let somebody else do the heavy lifting

Oh - and despite all of the computing power in the building at Ford, the first pre-production modular v8's were lining the teardown room with rods through the blocks. There's still stuff going on in these engines that demands experience and talent to get right.
So my message would be to maybe try some calculations as a very rough baseline, but then ask the guys who are really building and racing the FE. Here's another thing we got wrong with the Ford Modular V8: All of the FEA analysis optimized the block so that the bottom end would withstand no more than 460 HP. (It was felt that 100 HP/Liter at the 4.6L displacement was more than the engine would ever need to put out.)
Today that same block architecture, with some development mind you, is supporting over 1,200 HP in race trim. No one back in 1990 would have ever believed it was possible, even if you made the block out of titanium. Even if we had been able to study today's 1,200 HP Ford GT or Shelby version of the Modular, we would have figured maybe 500 or 600 HP tops. That's where years of building, racing, and tinkering can make the formulas and FEA models look pretty bad.