OK, so first, whats the difference between your 406 and this 410? Quench, heads, piston design, intake, ignition, carb, gearing etc.
The reason I ask is that like Paulie said earlier, DCR is just a tool, I run 8.35 on the Mustang and 8.2 in the truck and neither has fuel issues, matter of fact the Mustang is easier on fuel choices than the truck
So 8.0 vs 8.1 really is not significant, something else is contributing.
So for the use of the car though, I think the 265DEH on 106 would be OK, I'd probably run a 268H Comp though (for no good reason LOL) to peak around 4800-ish and I'd leave the quench tight. I'd look at the timing curve and mixture if it pings at that point. Typically the DEH cams are not very well loved for power, but it'd probably do fine for your needs.
Is your car a .64 OD and a 3.70?