Roll-out of tire, or circumference of tire always affects final drive ratio. It therefore affects gear multiplication in every gear. You will find that you have to start somewhere, and take a particular tire size that fits your vehicle, then change gear ratio in differential to make the most of that combination. I used a 10.5x29x15 on my '69 Mach I, and with a JPT C-4, I found that my 452MR would cross the line at 7200 with 4.57:1 gears. If I wanted more rpm, I would go to 4.88:1. You usually have to pick a size and then try it to see how it works. Go to the track and check out what everyone else is using, and you will save yourself some trial and error. Engine RPM(stroke/cam/valve springs/carburetion), horsepower, torque, vehicle weight, aerodynamics, all play a part in gear selection. Just don't select a gear that maxes your rpm out at the 1000ft mark when you still have 320ft more to go. Joe-JDC