In an engine like the 462 above, changing a Felpro 1020 to a 4.20 bore only gains .084:1 compression, 10.315 to 10.399.  Not sure I'd bother for the money.
However to answer the question, I have only done a couple at 4.375 and used a 4.40 Cometic and worked well.  So I would not be afraid of a 4.160 engine, assuming a properly prepped flat surface and a Cometic with a 4.190 or larger bore.  
Test fit if going close though, because every so often you get a weird one from Cometic, not common and I use them all the time, but have seen a couple that the bore was not centered