Like Rory mentioned, info about the car would help a lot.
My experience racing with a big in/out toploader. 497 hp 427 in my Mach 1 at 4460#. Quite a few hard years on the street before I started drag racing it, and never had a problem, but obviously traction was a saving point with street tires. Once I started racing, I went through 2 Drag Weeks, a couple of FE Reunions and a few Test & Tunes. At that point I was running mid 12's and still had no issues with slicks and launching hard, between 4k-5k (although occasionally breaking the tires loose), but that's when I started to have an occasional issue with hitting 2nd gear, mostly due to stock type synchros and shifting at 6000+. Still never broke anything, but it was wearing the synchros quicker. That's when I changed gearing and went with the Jerico, which dropped my times down to mid 11's.
Thor (XR7 on the forum) was a good example for the limits of the toploader. He started breaking them in his Cougar pretty regularly. I
think he was running in the mid 10's with it, and launching really hard, but still had a slipper clutch. He couldn't get them to last at that power and weight level. Although his car was lightened for racing, with the roll bars and added safety gear, it was still near regular weight levels for a Cougar I believe, maybe a little less.
There are no "special parts" that will stop them from breaking once you hit that point. Replacement parts are no better than stock parts, and doing "cryo" treatments and all that jazz is just trying to postpone the inevitable. Dog rings and pro-shifting etc, helps with shifts, but does nothing to add reliability from breakage. They will help save gears from tooth wear on engagement, but that's it.
Just my opinion based on what I've observed...
500 hp in a mid-weight car with slicks and a reasonable driver is about the limit before you can expect to start having problems....sooner or later.
Add power, or weight for a bigger car, and you can subtract reliability.
And like LarryK is fond of saying, some guys can break an anvil with a rubber mallet, so your mileage may vary
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