Mark, with 2.09/1.67 3/8 valves, I have seen the C8AE-H and D2TE-AA max out about 280 cfm, you could probably do a little better with 11/32 valves if you are building from scratch. You wouldn't want to turn them into C4 shape though, what you generally want to do is keep the intake small and fast and try to match med riser dimensions, which are much closer and pretty close to the same centerline.
That gets you much better flow and a smaller cross section than an Edelbrock out of the box, so sure, it'd run well. I run a set of D2s like that on my 445 and it's stronger than you'd expect for what it is.
Keep in mind though, without porting, that is a 220 cfm head, which would absolutely choke any FE worth it's salt, never mind a 482, so if you are going to port, recommend you do a serious port, a little cleaning isn't enough with a C8AE-H
However, the exhaust is pretty crappy for two reasons.
First, the exhaust port is lower by .250-ish compared to the bolts. Which means you need truck headers that are made for the C8/D2 or 390GT flanges from FPA or the like. It's a roll of the dice if car headers designed for C1/C3/C4 or CJ will seal because the ports are that much lower and won't support the gasket well. A final option is a full flange sealing header, or exhaust manifolds, the welding ring standard header will either leak, or eventually leak.
Second, the exhaust ports don't flow quite as well. That's not a real big deal with your cam size, but it's real tough to get the low exhaust port to 75% of intake without completely changing it. I'd say the best you'll likely get is 180 cfm-ish for closer to 65%. If you do that, I recommend a real good exhaust behind it and a well matched header to pull hard on the port
I wouldn't let either kill the deal though if you had headers to match already, as in my case on my F100, because of course headers designed for the C8/D2 will also leak on the C1/C4, so overall, the only real reason to pick that head is if you already had headers to fit them.