Well, technically there was a difference originally from Ford. By part number, early solid lifter motors (352 & 390 )and the '66 solid lifter police 428 used B8AZ-6563-A. Starting in '63 the 406 & 427 LR got shafts C3AZ-6563-A. From '65-'67 the medium riser 427 got C5AZ-6563-A. The medium riser shaft I believe is a tiny bit longer to make up for the wider valve spacing and wider shaft stands. All hydraulic cam FE's got B8AZ-6563-D shafts ( including the '68 hydraulic lifter 427 ). There are differences originally in the amount of holes. Now from a practical standpoint I agree with everyone else, it won't make much difference, except maybe if you have medium riser 427 heads. As CJShaker pointed out though, there is a top and bottom. The Ford shop manual will show how to orient the shafts.