Not that exact combo, but had trouble with clearance from the big end of the rod to the cam lobes (only a .440 lobe) on a couple of the rear 4 cylinders. That was with a 4.375 crank and Callies Ultra 6.700 BBC steel rods! With aluminum rods there would be even less clearance I would have to guess. Might help if you go to a 2.100 or 2.00 inch rod journal but then that is a custom crank (and rods). Other than that, might check clearance around the oil pump boss. Haven't had any clearance trouble with 4.250 in a Pond aluminum block, but again with Ultra steel rods. That one had a .480 lobe in it.