On my old 74 F350 ramp truck, I had both Hedman and Flow Tech long tube headers, with 2 1/2" exhaust pipes from the headers , to the tailpipes, which dumped at the rear axle. My truck was a NP435 4 speed, and did not have the long gas tank between the driveshaft and frame rails. Not sure if that would make any difference. Over the 26 years I had that truck, 2 different exhaust shops made up the exhaust systems , neither complained about it being any more difficult that any other fab job.