You just have to keep an eye on the amount of overlap you have when you're working with individual runner setups. With a solid flat tappet or solid roller, you're in a better situation because there's less major intensity. In contrast, a lot of the hydraulic rollers we use have a really high advertised duration in comparison to the .050" duration, so you're already at a disadvantage with the amount of overlap that you have. That's why you see a lot of individual runner camshafts on a 112-114 LSA. You will need to keep velocity high at the carburetor, or else you'll see a little cloud of fuel hovering over the engine.
It's certainly do-able, but there are too many variables at this point to nail down a .050" duration, advertised duration, LSA, etc.