Yeah, I used to use Dynosim 2000. It was very useful in my opinion.
I tested the program against real world dyno data over and over and over. That is when I had good data to input. Specifically, I wanted actual flow numbers for the heads and true compression ratios.
If I had good data to input, Dynosim was very accurate for peak hp. However it almost always inflated the peak torque (and below peak) and therefore the low rpm horsepower.
So, after a while of using it and comparing it to reality, I had a pretty good idea of how to interpret a Dynosim power curve so it would match real life. I made a spreadsheet to reduce the low rpm power to make more realistic.
Then I would input the "corrected" dyno data into my Drag 2000 program to get some fairly accurate 1/4 mile results. That program required some tweaking, as well.
The computer I had those programs on melted down so I haven't used the dyno or drag programs for a while.
That's my experience.
paulie