I'm not an expert, but I do have some math.
Recognizing that a crank is not in fact rigid, nor is the block, the internal harmonics can get pretty interesting. If the block was perfectly rigid you could assume that an out of balance plane between any two main bearing caps would have a fundamental frequency defined by the distance between the two caps. The fundamental frequency is the longest sinusoidal wave that can exist in that distance. This would occur at a specific RPM and would probably be the most destructive (or at least disturbing) frequency for the engine. The different crank segments have very similar length, and the engine has other unbalanced planes, each contributing their own wave, and since the block and crank are not perfectly rigid, they are also transmitted across the block and crank.
Add in the periodic shockwaves from combustion, valves closing and causing their own shock waves, and you have an interestingly complex mathematical problem. I suspect that the firing orders used by different manufacturers are in some way an attempt to reduce the compounding or wave super-position effect (two waves with different frequencies can overlap to either cancel or amplify the wave height) and use it to offset the waves.
This is manifestly obvious when you see a flat plane crank engine fire. It has no adjustments to crank angle and position to reduce the effect.
Short version is that each engine will probably have an RPM at which the combined wave forms give it the most destructive flex and vibration, and they probably do their best to minimize it at that frequency. Once they have done their best, they rely on the age old engineering practice - add in extra iron - so it won't fly apart.