If it were me, I'd likely port the heck out of them and run a 11/32 valve intake and exhaust assuming you are already buying guides and valves Likely a 1.67 valve is plenty, then use a 2.15 or even a 2.19 intake. You should be able to break the 300's without butchering the head.
I'd defer to Joe on what the 6x2 will breathe, but my guess is that the heads won't limit you