As an example of what a 3/8" fuel line and mechanical pump can achieve, my 63 Dodge has run 11.00sec in the 1/4 mile at 122mph with a 1.56sec 60' time. It has the standard fuel tank, 3/8" pick up in the standard sender, 3/8" fuel line up to the Carter HP street mechanical fuel pump and feeds the 2 Carter AFB's. It has no indications of fuel starvation, although I think having multiple carbs certainly helps. There is more fuel stored in the fuel bowls to start with than would be on a single 4 barrel carb.