Typically it is not the intake valve that is the problem, but the exhaust. Ford put a 2.250 in the TP and the HR heads on a standard bore 427. I don't see any problem with that, but again, if the valves have been moved any, then it will be a "trial fit" issue. The pistons will need to be notched to clear the larger valve, and valve placement is paramount to the notch. Radial clearance as well as depth is critical. All part of blueprinting. Joe-JDC.