Just to give you an example, when I remachined the bore centers on my Shelby block and moved the bores, I broke through the aluminum bore and into the water jacket area on three of the eight cylinders. This caused me a lot of trouble. What you would like is to have sufficient wall thickness on the block to allow the offset boring without breaking into the water jacket.
As described to me by the block manufacturer, in order to ensure this the casting patterns for the cores at the ends of the block would have to be changed, to allow room for the bores to be spread and still have sufficient water jacket at each end of the block. This would bulge the water jackets out a little at the front and rear of the block. All mounting surfaces would remain the same though, as I understand it, so the overall length of the block from the bellhousing mounting surface to the water pump and timing cover mounting surface would remain the same.
All I mean by angled pushrod is that the pushrod would be at an angle coming up from the lifter to the rocker, instead of coming straight up like they do on a standard FE.