I see this as potentially too little gearing for use. 28% reduction of 4.11 is a 2.95 gear, pretty tall, especially depending on tire height.
In my Mustang with a 27.5 inch tall tire, I went from about 12 mpg to 14 mpg, and a much more comfortable drive when going from 3.70s to 4.11. In town traffic was far better on fuel too. I went from 2.36 to 2.63 final, but my car is a lot lighter and less frontal area than a truck. I can't overdo how much nicer it was everywhere when I wasn't lugging and I also drive mine easy (until I don't LOL)
My truck does pretty well, but it is a 1:1 tranny 3.50 gear, 32 inch tall tire 4x4 with no overdrive. I will someday adapt an OD, but when I do it will likely get 4.56s or so
I am not advocating a gear change for mileage alone, but a gear change to 4.56 would put you at 3.28 final in OD (assuming I have the .72 number correct) and may make the truck happier on OD when unloaded, and certainly happier when loaded.
Just a thought.
I'd also add that OEMs have added intermediate gears (more gears) in a tranny to get mileage, they haven't hobbled performance, even the smaller motors, so you could spend a thousand or more as an experiment on cam change, maybe more with a smaller runner head swap, intake swap, new pistons, etc,, but you don't see the gasser modern trucks do it, they add 8 or 10 speed trannies so they get mechanical advantage everywhere and OD on top.