Personally, I like 180 cranks, in a V8 but, they do have a history of vibration.
Just recently, I read that the reason, for the vibration, is because all the weight is generated a cross from each other and not distributed more evenly around the crank, causing a undampened, "jerking" motion on the valve train, during the exhaust pulse.
Think of it as a rubber band, going back and forth, twice a revolution @ 90 deg from each other. As a though about how it might be dealt with, you might use a flywheel and dampener, with opposing weights at 90 deg to the throws. I think they may need a stronger flywheel retention for a BBF type flywheel.
Quotes are my opinion, only.
From what I've read, it has been dealt with by using dampeners in the valve train and long chain drives help the dampening, in DOHC designs. Some sort of dampener might be able to be made for the timing sprocket.
I wouldn't run one for a record run, this year but, if you have the money to burn, I think there is HP in it, if you can work it out.