With a SM or SD (my preference is the SD), Brent is right, without work, you'll lose power IMO on a 480+ inch engine compared to an RPM. I had an RPM with a little grinding, a stock SD and a stock SM on my 489 at certain points before the EFI and the SM petered out quickly, the SD not as bad, but the RPM ran real well WOT. The only changes to my RPM are a notched and shaped plenum, some porting on the roof to blend the turn under the carb, and a good port match to a med riser port. I think the changes would not be required with your RPM goals, but a port match and the roof work couldn't hurt.
That being said, my experience is that FE's love the small single planes for drivability from 400 cid and up if tuned correctly. I have not seen the loss of response on that size engine, and especially not on a 482. However, with your build goals, I agree that the RPM will run better part throttle with a dual plane.
I think the RPM is a good match