I used a wide ratio C6 with 3.25 gears many years ago. It was in '67 Cougar, approx. 3400 lbs. I had 27" tall tires.
I thought it worked pretty good with that rear gear. It wasn't ideal for 1/4 mile use as I wasn't using much of 3rd gear. I had a 2800 rpm converter at the time. It was good for crusing though. Later I added 3.75 rear gear with the wide ratio C6 and I didn't like that combo. It was too much 1st gear ratio.
Later I went back to a standard ratio gearset in a C6. It worked better with the 3.75 rear gear. Then I went to a 4.11 rear gear, better yet.
So for cruising or hobby use with a high (numerically low) rear gear, I think the wide ratio gearset works well. If I had a 2.75, 3.00, or 3.25 rear gear I would consider it. If I had a heavy and/or relatively low powered car I would consider using it with a 3.50 rear gear.
With lower (numerically high) rear gears I would tend to stay away from the wide ratio gearset. Also, with a higher powered and/or lighter car, it isn't as desirable.
Any more details on your combo? Type of car? Cam and rpm range?
paul