For peak hp numbers, I agree that you need to feed the beast, and the 12-15 degrees seems pretty close
However, remember that you are also changing overlap, advertised valve timing, and the engine has a different piston dwell time and cylinder fill capability, etc. To go from a 224 degree 390 to a 236 degree 445 with the added overlap, I think you'd have a little rowdier engine than you expected, not radical, but a little more choppy idle.
If you use the 12-15 degree increase, I think I'd spread the centers to maintain the same overlap and keep the intake lobe timing early. That way you wouldn't lose part throttle low rpm behavior, but you'd get the cylinder fill.
What I think is more important as you go up in displacement is intake and cylinder head selection. You'll go far by making a deep breather using heads and intake, then camming for where you plan to use it the most
BTW, I used a 270H in my 445, rolled it back to 110 ICL and wonder sometimes if I should have went 112, but mostly because I had a tough time getting to the DCR I wanted.
With that being said, I did it because I was being cheap and I had a good cam and lifters matched to the block I used, already broken in. We'll see how it does, the heads flow 280 and the RPM intake was worked and balanced. Hopefully the heads and intake will hold on at the upper end of the curve
No doubt it would make more power with more cam, but in a 4x4 with 3.50 gears and 33 inch tall rubber, we'll see how it does when I get the body back together. It sounds REAL strong, but the story will be told when the tach hits 5K LOL