If I had the time and money, I wouldn't mind trying it for fun. If we're talking FE's, I probably would stay relatively low displacement...like 352ish. I have an FE I like for towing and it's about the limit (just over 600 lbft) I feel okay with considering the tranny choices that attach to FE's. And it's plenty for what I'm towing.
Are you talking about adding one to an FE and what tranny would you use?