I assume you are getting the 48 IDAs? My book has data on the Weber setup, with the 390 stroker engine (446"), the 427 sideoiler, and the 427 stroker (492"). I've only tuned them on the dyno, but it wasn't that tough; only problem is if you want to change jets, or air bleeds, you need 8 of everthing. Those 48 IDA carbs will limit your power production, though. If you are shooting for 600 HP or higher, they are not a good choice; they just can't flow the air the engine will need. They are well matched on a 500-550 HP engine, and will make more average power than anything else in an engine like that, but if you exceed that power level, they will hold you back.
If there was some way you could run 58 IDAs instead of 48 IDAs, it might be a much different story...