BTW, I ran my first 427 in my Mustang at over .100 below deck, with a 300 adv/250@.050 cam, Portosonic intake, close ratio 4 speed, 3.70s and an 850 double pumper, it wasn't the fastest 427, but it sounded it, was dead nuts reliable and brought me all over CA and NV
So I cant say I'd start with a clean slate and have a ton of quench and too much cam, but it doesn't make them fragile either. Sometimes just assemble, run it, enjoy the car and plan for the next one.