So, it's all about the ability to tune it.
Self tuning is a real good thing, but, it should be considered as an "self-adjustment to a good tune" not "the creation of the tune"
That is where some of these TB systems have issues, you just don't have the ability to create a good base tune with 4-5 questions. As Jay said, taking fuel distribution issues out by using port injection is a very good thing, but I have a hunch that 4 properly size injectors in a TB, combined with ignition control, would still do real well if driven by a Megasquirt or some other system that would allow more manipulation and the ability to learn (and the ability to prevent learning in some conditions)
The other thing I will bring up is, a guy who loves his carb usually doesn't go EFI. So guys who are replacing a "carb that can't be tuned" may not be too happy with a TB system either, one because if you can't tune a carb, you can't tune EFI (insert tuna fish joke here) but also because often the carb issue is not because of the carb, so the EFI likely can't fix it.
As far your application, it's pretty expensive to set up to port injection compared to a cheap TB system, it depends if you think the truck is worth it. I have used many different setups, and I think if I go EFI on my truck, I will use a Megasquirt to drive a TB, I have even considered a EEC-IV speed density system off a 4 cylinder because I know this insides of that program. In either case, less benefit than a port injection, but more control than an out of the box TB.
FYI - The MOST controllable cheap TB system I have installed and tuned is the Professional Products Powerjection, but the hardware itself is crappy, so what you get for a computer based ability to tune, you lose in junky parts.