Tom, anything can be made to fit. I cracked a piston on my '72 Pinto, running with a pair of side-draft Webers and all the other stuff you'd expect. While re-doing the engine, I was looking at another project, a 429 SCJ engine setting on the floor, that we re-worked with a 460 crank for a local circle-track car that was sorta in the family.
Long story short, I put a full frame in it, chopped the top 4 inches, put a roll-cage in it, and the 466/C6 combo with a Versailles 9" rear axle. We set the engine behind the original firewall line and mounted two seats on the back seat footspace. Fibreglas front end, doors and rear quarters with 285-40X15 front tires and 335-35X15 Pirellis on the back, all on Weld wheels. Used the engine box from an E150 as the starting point for the new firewall. The driveshaft was only a bit more than a foot long. Car weighed 2260 with 1140 on the rear wheels. (I was writing for Super Ford at the time.)
Great fun until it was stolen.
KS