If you want to increase the responsiveness of the engine, how quick it can rev, you need to decrease the moment of inertia. This is why a shorter stroke will rev higher. But the moment of inertia also takes into account your reciprocating mass, so making everything as light as possible helps as well, to increase the acceleration of the engine. How reliable the engine will be will take into account your valvetrain as well, making this as light as possible helps you keep revving higher, longer. At this point, your gearing will also come into play as to how quick your engine will accelerate. I should note that the moment of inertia for your drivetrain will come into play. Light weight transmission gears, differential and the rotating mass of your rims and tires. This is part of the reason why carbon fiber and magnesium rims are there, the lower weight helps make the vehicle accelerate faster due to the engine having to work less to move the rotating mass. Another reason for these rims is by having less weight on your unsprung weight, there will be less force behind suspension travel.